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Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):

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Delphi survey to explore core curriculum for training the next-generation of hepatologists<sup>☆</sup>.

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Related Experiment Video

Updated: May 7, 2026

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
07:13

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

Published on: April 20, 2021

Noninvasive evaluation of NAFLD.

Laurent Castera1, Valérie Vilgrain, Paul Angulo

  • 1Department of Hepatology, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Université Paris Sorbonne Cité, and INSERM CRB3, Centre de Recherche Biomédicale Bichat-Beaujon, Unité 773, 100 Boulevard du Général Leclerc, 92110 Clichy, France.

Nature Reviews. Gastroenterology & Hepatology
|September 25, 2013
PubMed
Summary

Noninvasive methods help assess liver health in Non-Alcoholic Fatty Liver Disease (NAFLD). These tools aid in identifying patients needing liver biopsies for accurate diagnosis and fibrosis staging.

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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
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Published on: March 24, 2023

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Last Updated: May 7, 2026

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
07:13

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

Published on: April 20, 2021

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

Area of Science:

  • Hepatology
  • Gastroenterology
  • Medical Diagnostics

Background:

  • Non-Alcoholic Fatty Liver Disease (NAFLD) diagnosis and staging are critical for patient management.
  • Distinguishing simple steatosis from Non-Alcoholic Steatohepatitis (NASH) and assessing fibrosis stage are key clinical concerns.
  • Advanced fibrosis in NAFLD patients significantly increases the risk of end-stage liver disease complications.

Purpose of the Study:

  • To review the advantages and limitations of noninvasive methods for managing adult NAFLD patients.
  • To discuss the role of noninvasive techniques in diagnosing and quantifying steatosis.
  • To evaluate noninvasive markers for NASH diagnosis and hepatic fibrosis staging.

Main Methods:

  • Review of existing literature on noninvasive diagnostic tools for NAFLD.
  • Discussion of ultrasonography, controlled attenuation parameter (CAP), cytokeratin-18, transient elastography, and the NAFLD fibrosis score.
  • Analysis of the accuracy and applicability of various noninvasive markers.

Main Results:

  • Ultrasonography is a sensitive tool for steatosis screening, while CAP requires further validation.
  • Cytokeratin-18 is a validated but imperfect serum marker for NASH.
  • The NAFLD fibrosis score demonstrates good accuracy in distinguishing advanced fibrosis.
  • Transient elastography can exclude advanced fibrosis but has limitations in NAFLD patients.

Conclusions:

  • Noninvasive methods show promise for managing NAFLD, including steatosis assessment and fibrosis staging.
  • Further validation is needed for some noninvasive techniques.
  • These methods can aid in selecting NAFLD patients who require liver biopsy for definitive diagnosis.