ZnO Nanoparticles as New and Efficient Catalyst for the One-pot Synthesis of Polyfunctionalized Pyridines

In this research, an efficient one-pot synthesis of 2-amino-3,5-dicyano-4-phenyl-6-(phenylthio)pyridines has been developed via multi-component reaction of aldehydes, thiols and malononitrile in the presence of ZnO nanoparticles. Poly-substituted pyridines as heterocyclic privileged medicinal scaffolds are prepared via carbon-carbon and carbon-heteroatom bond formation. The present methodology provides a novel and efficient method for the synthesis of pyridine derivatives with some advantages such as short reaction times, excellent yields, recoverability and low catalyst loading.