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Related Experiment Video

Updated: May 7, 2026

Generating Genetically Modified Plasmodium berghei Sporozoites

Generating Genetically Modified Plasmodium berghei Sporozoites

Published on: May 5, 2023

Malaria vaccines: past, present and future.

Lorenz von Seidlein¹, Philip Bejon

¹Department of Global health, Menzies School of Health Research, , Casuarina, Northern Territory, Australia.

Archives of Disease in Childhood

|September 25, 2013

Summary

Developing a safe and effective malaria vaccine is crucial for global health. Current vaccine candidates target various Plasmodium parasite stages, with combination approaches showing promise for complete protection.

Keywords:

Infectious Diseases Tropical Inf Dis Tropical Paediatrics

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Last Updated: May 7, 2026

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Published on: August 6, 2020

Area of Science:

Tropical medicine
Vaccinology
Parasitology

Background:

Malaria remains a significant global health challenge, with current control tools insufficient for elimination in many endemic regions.
A safe and effective malaria vaccine represents a critical advancement for disease control and potential elimination efforts.

Purpose of the Study:

To review the landscape of malaria vaccine candidates targeting different stages of the Plasmodium parasite lifecycle.
To discuss the challenges and potential of various vaccine strategies, including pre-erythrocytic, blood-stage, and transmission-blocking approaches.

Main Methods:

Review of existing literature on malaria vaccine development.
Analysis of different vaccine candidate types, including subunit (e.g., RTS,S/AS01), whole-parasite, and prime-boost strategies.
Evaluation of immunological responses and challenges associated with each approach.

Main Results:

The RTS,S/AS01 vaccine targeting pre-erythrocytic stages is the most advanced candidate.
Attenuated whole-parasite vaccines show high protective potential but face manufacturing and administration hurdles.
Prime-boost strategies elicit strong immune responses, and targeting blood or sexual stages presents unique challenges and opportunities.

Conclusions:

No single-antigen malaria vaccine is likely to provide complete protection due to Plasmodium's complexity.
Combination antigen strategies and a systematic search for novel targets offer a more promising path toward highly effective malaria vaccines.