Related Experiment Video

Updated: May 7, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Spectrophotometric determination of acidity constants of some macrolides in acetonitrile-water binary mixtures

Senem Sanli, Nurullah Sanli, Güleren Alsancak

    Acta Chimica Slovenica
    |September 25, 2013
    PubMed

    More Related Videos

    Determination of the Gas-phase Acidities of Oligopeptides11:00

    Determination of the Gas-phase Acidities of Oligopeptides

    Published on: June 24, 2013

    Related Concept Videos

    Titration Calculations: Weak Acid - Strong Base03:55

    Titration Calculations: Weak Acid - Strong Base

    Calculating pH for Titration Solutions: Weak Acid/Strong Base
    For the titration of 25.00 mL of 0.100 M CH3CO2H with 0.100 M NaOH, the reaction can be represented as:
    Titration of a Weak Acid with a Weak Base01:08

    Titration of a Weak Acid with a Weak Base

    Weak acids and bases do not undergo dissociation completely, and titrations between these two are rarely studied. When such studies are performed, say, for the titration of a weak acid with a weak base, the titration curve plots the change in pH as a function of the volume of base added. Take the titration of acetic acid with ammonia, for instance. During the titration, these two species form ammonium acetate and water, but the pH change is slow and gradual.
    As a result, there is no simple...
    Mixtures of Acids03:27

    Mixtures of Acids

    The pH of a solution containing an acid can be determined using its acid dissociation constant and its initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending upon the relative strength of the acids and their dissociation constants.
    A Mixture of a Strong Acid and a Weak Acid
    In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
    Mixtures of Acids01:19

    Mixtures of Acids

    The pH of a solution containing an acid can be determined using its acid dissociation constant and initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending on the relative strength of the acids and their dissociation constants.
    In a strong and weak acid mixture, the strong acid dissociates completely and becomes a source of almost all the hydronium ions present in the solution. In contrast, the weak acid shows...
    Titration of a Weak Acid with a Strong Base01:30

    Titration of a Weak Acid with a Strong Base

    In titrating a weak acid with a strong base, different calculation methods are applied at various stages. Initially, the pH of a weak acid like acetic acid is calculated using its dissociation constant (Ka) and an ICE table. Upon addition of a strong base such as sodium hydroxide, a buffer forms, and its pH is determined using the Henderson-Hasselbalch equation. As more base is added and the titration reaches the halfway point, the pH becomes equal to the pKa of the acid, indicating equal...
    Solution Composition During Acid/Base Titrations01:17

    Solution Composition During Acid/Base Titrations

    The titration of a weak acid with a strong base results in the formation of water and the conjugate base of the acid. For instance, titrating acetic acid with sodium hydroxide leads to the formation of water and sodium acetate. A solution of acetic acid and sodium acetate constitutes a buffer whose relative concentration at different stages of the titration is indicated by the α values, which represent percentages of the weak acid and its conjugate base.
    The α0 and α1 values represent the...