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Related Experiment Video

Updated: May 7, 2026

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

Published on: November 1, 2019

Using the COREX/BEST server to model the native-state ensemble.

Vincent J Hilser¹, Steven T Whitten

¹Departments of Biology and Biophysics, Johns Hopkins University, Baltimore, MD, USA.

Methods in Molecular Biology (Clifton, N.J.)

|September 25, 2013

Summary

This summary is machine-generated.

A new web server, COREX/BEST, models protein structures as dynamic microstates using statistical thermodynamics. This tool helps researchers analyze protein ensemble properties and thermodynamic behavior.

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Area of Science:

Structural Biology
Computational Biology
Biophysics

Background:

Proteins exist as dynamic ensembles of interconverting microstates.
Understanding these ensembles is crucial for protein function and stability.

Purpose of the Study:

To introduce a web-based implementation of the COREX/BEST algorithm.
To provide a tool for characterizing native protein ensemble properties.

Main Methods:

Development of the COREX/BEST Server, a web-based platform.
Utilizing statistical thermodynamics to model protein microstates.
Validation through experimental comparisons of biophysical phenomena.

Main Results:

The COREX/BEST Server enables detailed analysis of protein structural and thermodynamic properties.
Demonstrated utility in characterizing native protein ensembles.

Conclusions:

The COREX/BEST Server offers a valuable online resource for protein structure and dynamics research.
Facilitates the study of protein behavior in statistical thermodynamic terms.