Related Experiment Video
Updated: Feb 10, 2026
06:37
Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package
Published on: September 17, 2021
5.1K
Study of Immediate Release Spherical Microparticles Containing Clarithromycin using a Hot-melt Fluid Bed Technique
Acta Chimica Slovenica
|September 25, 2013
Summary
This study optimized hot-melt microparticle preparation for clarithromycin, finding polyethylene glycol (PEG) binders yielded better results than PEG-32 glyceryl laurate. The hot-melt technique improved drug release compared to traditional wet granulation methods.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Immediate release microparticles are crucial for effective drug delivery.
- Hot-melt extrusion is a promising technique for microparticle fabrication.
- Optimizing binders and process parameters is key to achieving desired microparticle characteristics.
Purpose of the Study:
- To evaluate the hot-melt technique for preparing immediate release spherical microparticles containing clarithromycin.
- To assess the impact of different meltable binders (Poloxamer 188, PEG-32 glyceryl laurate, and polyethylene glycol mixtures) on microparticle properties and process yield.
- To identify and optimize key process parameters influencing microparticle characteristics.
Main Methods:
- Spherical microparticles (125-355 µm) were prepared using a modified fluid bed apparatus with a rotor insert.
- Meltable binders including Poloxamer 188, PEG-32 glyceryl laurate (Gelucire 44/14), and polyethylene glycol (PEG) 4000/400 mixtures were employed.
- Process parameters were optimized to determine their influence on process yield and microparticle characteristics, with a focus on bed temperature.
Main Results:
- Microparticles prepared with Poloxamer 188 and PEG binders demonstrated favorable mechanical properties and acceptable process yields (approx. 60-70%).
- PEG binders generally offered better process stability and yield compared to PEG-32 glyceryl laurate.
- The hot-melt technique resulted in improved clarithromycin dissolution rates and equilibrium concentrations compared to wet granulation methods.
Conclusions:
- The hot-melt technique is a viable method for producing immediate release clarithromycin microparticles with good characteristics.
- Polyethylene glycol (PEG) and Poloxamer 188 are suitable binders for this hot-melt process, offering improved mechanical properties and yield.
- This optimized hot-melt granulation process enhances drug release profiles, presenting an advantage over conventional wet granulation.
Related Concept Videos
01:23Spherical Coordinates
16.2K
Spherical coordinate systems are preferred over Cartesian, polar, or cylindrical coordinates for systems with spherical symmetry. For example, to describe the surface of a sphere, Cartesian coordinates require all three coordinates. On the other hand, the spherical coordinate system requires only one parameter: the sphere's radius. As a result, the complicated mathematical calculations become simple. Spherical coordinates are used in science and engineering applications like electric and...
16.2K
01:20Capillary Beds
7.3K
Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
Capillaries connect arterioles, small branches of arteries, to venules,...
Capillaries connect arterioles, small branches of arteries, to venules,...
7.3K
02:39Phase Transitions: Melting and Freezing
15.3K
Heating a crystalline solid increases the average energy of its atoms, molecules, or ions, and the solid gets hotter. At some point, the added energy becomes large enough to partially overcome the forces holding the molecules or ions of the solid in their fixed positions, and the solid begins the process of transitioning to the liquid state or melting. At this point, the temperature of the solid stops rising, despite the continual input of heat, and it remains constant until all of the solid is...
15.3K
02:34Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility
51.7K
Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
51.7K
01:20Hot Weather Concreting
319
Concreting at elevated temperatures accelerates the hydration process, leading to quicker setting but potentially reducing the long-term strength of the concrete structure. Additionally, low air humidity fosters rapid moisture loss from the concrete, resulting in reduced workability, pronounced plastic shrinkage, and a higher likelihood of crazing.
Mitigating the heat increase in concrete can be economically achieved by shading aggregate stockpiles to prevent heating from solar radiation,...
Mitigating the heat increase in concrete can be economically achieved by shading aggregate stockpiles to prevent heating from solar radiation,...
319
01:27Gravity between Spherical Bodies
9.5K
Newton's law of gravitation describes the gravitational force between any two point masses. However, for extended spherical objects like the Earth, the Moon, and other planets, the law holds with an assumption that masses of spherical objects are concentrated at their respective centers.
This assumption can be proved easily by showing that the expression for gravitational potential energy between a hollow sphere of mass (M) and a point mass (m) is the same as it would be for a pair of extended...
This assumption can be proved easily by showing that the expression for gravitational potential energy between a hollow sphere of mass (M) and a point mass (m) is the same as it would be for a pair of extended...
9.5K