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Bacterium-like particles for efficient immune stimulation of existing vaccines and new subunit vaccines in mucosal
Natalija Van Braeckel-Budimir1, Bert Jan Haijema, Kees Leenhouts
1Mucosis BV , Groningen , Netherlands.
Abstract:
The successful development of a mucosal vaccine depends critically on the use of a safe and effective immunostimulant and/or carrier system. This review describes the effectiveness and mode of action of an immunostimulating particle, derived from bacteria, used in mucosal subunit vaccines. The non-living particles, designated bacterium-like particles are based on the food-grade bacterium Lactococcus lactis. The focus of the overview is on the development of intranasal BLP-based vaccines to prevent diseases caused by influenza and respiratory syncytial virus, and includes a selection of Phase I clinical data for the intranasal FluGEM vaccine.
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