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Updated: May 7, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis and quantitative structure-activity relationship study of substituted imidazophosphor ester based
Wafaa M Abdou1, Neven A Ganoub, Eman Sabry
1Chemical Industries Division, National Research Centre, Elbohouth St. D-12311, Dokki, Cairo, Egypt.
Abstract:
A high-yielding general synthesis of imidazophosphor ester based tetrazolo[1,5-b]pyridazines is described. A conjugated reaction between 3,6-diazidopyridazine and different types of phosphonyl carbanion reagents followed by intramolecular cyclization afforded the target products, by using sodium ethanolate solution as a reaction medium. Among the products, five compounds, at a dose of 50 mg per kilogram body weight, showed a notable antinociceptive and anti-inflammatory activity without toxic side-effects.
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