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Updated: May 7, 2026

Profiling of Permethylated Mucin O-glycans Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry
Published on: June 20, 2025
Synthesis of mucin-type O-glycan probes as aminopropyl glycosides
David Benito-Alifonso1, Rachel A Jones, Anh-Tuan Tran
1School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK , Tel: (0)1179287654.
Abstract:
The chemical synthesis of a series of mucin-type oligosaccharide fragments 1-7 containing an α-linked aminopropyl spacer ready for glycoarray attachment is reported. A highly convergent and stereoselective strategy that employs two different orthogonal protected galactosamine building blocks was used to access all of the targets. A tandem deprotection sequence, that did not require chromatography-based purification between steps, was employed to globally unmask all protecting groups and all final targets were isolated in good to excellent yields.
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