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Updated: May 7, 2026
06:40
An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
Published on: June 8, 2021
[Regional anesthesia and cancer immunology]
Toru Igarashi1, Katsuya Mori, Kei Inoue
1Department of Anesthesiology, Keio University School of Medicine, Tokyo 160-8582.
Masui. the Japanese Journal of Anesthesiology
|September 26, 2013
Summary
Regional anesthesia may reduce cancer recurrence by improving anti-tumor immunity during surgery. This approach offers potential long-term benefits for cancer patients undergoing perioperative care.
Area of Science:
- Anesthesiology
- Immunology
- Oncology
Context:
- Regional anesthesia is a common method for perioperative pain management.
- Emerging evidence suggests regional anesthesia may reduce surgical site infections and cancer recurrence.
- Cancer patients often experience suppressed innate immunity, increasing metastasis risk.
Purpose:
- To review the impact of regional anesthesia on tumor immunity during the perioperative period.
- To discuss how perioperative factors depress anti-tumor immunity.
- To explore the potential of regional anesthesia in mitigating these effects.
Summary:
- Perioperative periods significantly depress tumor immunity due to pain, sympathetic activation, and inflammation.
- Regional anesthesia may counteract these immunosuppressive effects.
- This review focuses on alterations in tumor immunity and the role of regional anesthesia.
Impact:
- Regional anesthesia shows promise in improving long-term outcomes for cancer patients.
- Minimizing cancer recurrence is a critical benefit.
- Further research into regional anesthesia's immunomodulatory effects is warranted.
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