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[Fluctuant hypertension and platelet activation: current situations and control strategies with integrative medicine]

Yue Liu1, Jing-Chun Zhang, Da-Zhuo Shi

  • 1Center for Cardiovascular Disease, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|September 26, 2013
PubMed

Insights

Fluctuant hypertension worsens target organ damage and increases cardiovascular events compared to stable hypertension. This study links it to a prothrombotic state involving platelet activation and endothelial dysfunction.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Traditional Chinese Medicine (TCM)

Context:

  • Fluctuant hypertension, unlike stable hypertension, is increasingly recognized for its detrimental effects on target organs and increased risk of acute cardiovascular and cerebrovascular events.
  • The precise mechanisms underlying thromboembolic target organ damage in hypertensive patients, particularly the role of platelet activation, remain incompletely understood.
  • Managing fluctuant hypertension and preventing its associated organ damage are critical challenges in global hypertension research.

Purpose:

  • To explore the relationship between fluctuant hypertension, platelet activation, and the concept of blood stasis syndrome in Traditional Chinese Medicine.
  • To elucidate the pathophysiological state associated with fluctuant hypertension, specifically focusing on prothrombotic conditions and endothelial dysfunction.
  • To investigate the potential therapeutic applications of Chinese medicine herbs that activate blood circulation and resolve stasis for managing fluctuant hypertension.

Summary:

  • Clinical studies indicate that fluctuant hypertension exacerbates target organ damage and elevates the risk of acute cardio-/cerebrovascular events more than stable hypertension.
  • This research proposes that fluctuant hypertension induces a prethrombotic state characterized by platelet activation, heightened thrombopoiesis, and endothelial dysfunction.
  • Blood stasis syndrome, a concept in Traditional Chinese Medicine, may be a key diagnostic marker for fluctuant hypertension, suggesting a therapeutic role for related herbal treatments.

Impact:

  • Highlights the significance of platelet activation and endothelial dysfunction in the pathophysiology of fluctuant hypertension.
  • Suggests a potential diagnostic and therapeutic framework for fluctuant hypertension by integrating Western medicine and Traditional Chinese Medicine principles.
  • Identifies a promising avenue for developing novel treatments for fluctuant hypertension using blood-activating and stasis-resolving herbal therapies.

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