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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
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Published on: December 5, 2015

Maternal stress and placental vascular function and remodeling

Lawrence P Reynolds1, Kimberly A Vonnahme, Caleb O Lemley

  • 1Department of Animal Sciences, NDSU 7630, P.O. Box 6050, Fargo, ND 58103-6050, USA. larry.reynolds@ndsu.edu.

Current Vascular Pharmacology
|September 26, 2013
PubMed

This review discusses the importance of placental vascular development, as reflected by placental angiogenesis and placental blood flow, to placental function in normal pregnancies. We then summarize our current understanding of how maternal stress, including inadequate maternal nutrition as well as the application of assisted reproductive technologies (ART), leads to compromised placental angiogenesis and function and the subsequent effects on fetal and neonatal growth and development. Finally, we discuss several promising therapeutic approaches to 'rescue' placental vascular development and function in compromised pregnancies, leading to improved pregnancy and postnatal outcomes.

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