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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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Biocompatible shaped particles from dried multilayer polymer capsules.

Jun Chen1, Veronika Kozlovskaya, Allison Goins

  • 1Department of Chemistry, University of Alabama at Birmingham , Birmingham, Alabama, United States.

Biomacromolecules
|September 26, 2013
PubMed
Summary
This summary is machine-generated.

Researchers developed a method to create biocompatible hollow microparticles with controlled shapes like hemispheres, spheres, and cubes. These particles are non-toxic and can be tuned for biomedical applications, showing potential for cellular uptake studies.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Fabricating biocompatible microparticles with precise control over shape and size is crucial for advanced biomedical applications.
  • Existing methods often lack versatility in shape control or biocompatibility.

Purpose of the Study:

  • To develop a facile and robust method for producing monodisperse, biocompatible hollow microparticles with tunable geometries.
  • To investigate the shape transformation mechanisms and the influence of material properties on particle morphology.
  • To evaluate the biocompatibility and cellular uptake of the fabricated microparticles.

Main Methods:

  • Fabrication of multilayer capsules using hydrogen-bonded poly(N-vinylpyrrolidone)/tannic acid (PVPON/TA)n.
  • Controlled drying of capsules to induce shape transformations into hemispherical, spherical, or cubical hollow microparticles.
  • Characterization of particle morphology, stiffness, and dimensional control.
  • Assessment of particle resuspension, rehydration, and shape retention.
  • In vitro cytotoxicity studies using human cancer cells and cellular uptake studies with macrophages.

Main Results:

  • Successfully fabricated monodisperse hollow microparticles with hemispherical, spherical, and cubical geometries.
  • Demonstrated shape transformation from spherical to hemispherical based on layer number (15 < n < 20), controlled by capsule stiffness.
  • Achieved stable 3D shapes (cubical and spherical) in dry state for n ≥ 25.5, with a 17-fold stiffness increase observed.
  • Particles were resuspendable and retained shape upon rehydration.
  • Exhibited non-cytotoxic properties and differential cellular uptake by macrophages, with hemispherical particles showing higher efficiency.

Conclusions:

  • The PVPON/TA multilayer system provides a versatile platform for creating biocompatible, shape-controlled hollow microparticles.
  • Particle shape and dimensions can be precisely tuned by controlling capsule size and wall thickness (layer number).
  • These tunable, biocompatible microparticles hold significant potential for various biomedical applications, including targeted cellular uptake and microfluidic studies.