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Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
Cytotoxic deoxybenzoins and diphenylethylenes from Arundina graminifolia
Qiu-Fen Hu1, Bin Zhou, Yan-Qing Ye
1Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.
Abstract:
Eight new C-4-alkylated deoxybenzoins (1-8), three new diphenylethylenes (9-11), and five known diphenylethylenes were isolated from Arundina graminifolia. The structures of 1-11 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 9-11 are the first naturally occurring diphenylethylenes possessing a hydroxyethyl unit. Compounds 1-11 were evaluated for cytotoxicity against five human tumor cell lines. Compounds 4, 5, and 9-11 showed significant cytotoxicity against five cancer cell lines, with IC50 values ranging from 1.8 to 8.7 μM.
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