Statistical design for biospecimen cohort size in proteomics-based biomarker discovery and verification studies

Steven J Skates1, Michael A Gillette, Joshua LaBaer

  • 1Biostatistics Center, Massachusetts General Hospital Cancer Center , Boston, Massachusetts 02114, United States.

Journal of Proteome Research
|September 26, 2013
PubMed
Summary

Developing robust protein biomarkers for cancer requires overcoming analytical and clinical hurdles. This study introduces a statistical framework to determine appropriate sample sizes for proteomic studies, enhancing biomarker discovery and verification.