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Updated: May 7, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer

Yong I Cha1, Hyun-Seok Kim

  • 1Department of Life Science, Ewha Womans University, Seoul 120-750, Korea kimhs0601@ewha.ac.kr.

BMB Reports
|September 26, 2013
PubMed

Insights

Aging and cancer are linked through molecular pathways. This review focuses on Sirtuins 2-7, exploring their emerging roles in cancer development beyond the well-studied Sirtuin 1.

Area of Science:

  • Molecular biology
  • Gerontology
  • Oncology

Background:

  • Aging is the primary risk factor for cancer, indicating shared molecular pathways.
  • Sirtuins (Sirt1-7) are key regulators of cellular processes implicated in aging and cancer.
  • While Sirtuin 1's role in cancer is documented, the functions of Sirtuins 2-7 remain less understood.

Purpose of the Study:

  • To review the emerging roles of Sirtuins 2-7 in carcinogenesis.
  • To highlight the potential of Sirtuins 2-7 as molecular links between aging and cancer.

Main Methods:

  • Literature review of recent studies on Sirtuins 2-7 and cancer.
  • Analysis of Sirtuin involvement in cellular pathways relevant to tumorigenesis.

Main Results:

  • Sirtuins 2-7 modulate critical cellular pathways including DNA repair, metabolism, and proliferation.
  • Evidence suggests Sirtuins 2-7 can act as either tumor suppressors or promoters depending on context.
  • These sirtuins represent a significant, yet understudied, area in aging and cancer research.

Conclusions:

  • Sirtuins 2-7 play crucial, context-dependent roles in cancer development.
  • Further research into Sirtuins 2-7 is essential for understanding the aging-cancer axis.

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