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Updated: May 7, 2026

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
Published on: May 13, 2020
Stochastic modeling of short-term exposure close to an air pollution source in a naturally ventilated room: an
Kai-Chung Cheng1, Viviana Acevedo-Bolton2, Ruo-Ting Jiang2
11] Civil and Environmental Engineering Department, Stanford University, Stanford, California, USA [2] Indoor Air Quality Section, Environmental Health Laboratory, California Department of Public Health, Richmond, California, USA.
Abstract:
For an actively emitting source such as cooking or smoking, indoor measurements have shown a strong "proximity effect" within 1 m. The significant increase in both the magnitude and variation of concentration near a source is attributable to transient high peaks that occur sporadically-and these "microplumes" cause great uncertainty in estimating personal exposure. Recent field studies in naturally ventilated rooms show that close-proximity concentrations are approximately lognormally distributed. We use the autocorrelated random walk method to represent the time-varying directionality of indoor emissions, thereby predicting the time series and frequency distributions of concentrations close to an actively emitting point source. The predicted 5-min concentrations show good agreement with measurements from a point source of CO in a naturally ventilated house-the measured and predicted frequency distributions at 0.5- and 1-m distances are similar and approximately lognormal over a concentration range spanning three orders of magnitude. By including the transient peak concentrations, this random airflow modeling method offers a way to more accurately assess acute exposure levels for cases where well-defined airflow patterns in an indoor space are not available.
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