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Oncogenes and leukemia.

A Butturini1, R P Gale

  • 1Department of Pediatrics, University of Parma, Italy.

Leukemia
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Abnormalities in cellular oncogenes are frequent in human leukemias, arising from mutations or translocations. Understanding their role could lead to new diagnostic and therapeutic strategies for leukemia.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cellular oncogenes (proto-oncogenes) regulate normal cell growth and development.
  • Abnormal oncogene expression is linked to altered cell growth and malignant transformation, particularly in human leukemias.
  • Multiple mechanisms, including mutation, translocation, and amplification, can cause oncogene abnormalities in leukemia cells.

Purpose of the Study:

  • To explore the role of cellular oncogenes in the pathogenesis of human leukemias.
  • To identify specific oncogene abnormalities associated with different types of leukemia.
  • To investigate the potential for developing innovative diagnostic and therapeutic strategies based on oncogene function.

Main Methods:

  • Analysis of oncogene abnormalities (mutation, translocation, amplification) in various human leukemia subtypes.

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  • Comparison of oncogene alterations in leukemia cells versus normal cells.
  • Review of existing literature on oncogene function and leukemogenesis.

    • Main Results:

    • Oncogene abnormalities are common in many human leukemias, though uncommon in others like most acute lymphoblastic leukemia and chronic lymphocytic leukemia.
    • Specific oncogene abnormalities are associated with particular leukemias (e.g., ABL in chronic myelogenous leukemia, MYC in Burkitt leukemia/lymphoma).
    • Some oncogenes encode growth factors or receptors, while others regulate cell proliferation and differentiation; disruption of these processes is implicated in leukemogenesis.

    Conclusions:

    • Oncogene abnormalities play a significant role in the development of human leukemias.
    • The precise mechanisms by which oncogenes contribute to leukemia pathogenesis require further definition.
    • Defining the role of oncogenes may pave the way for novel diagnostic tools and targeted therapies for leukemia.