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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

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Related Experiment Video

Updated: May 7, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Small bowel amyloidosis.

Milena Gould1, Neda Zarrin-Khameh, Joseph Sellin

  • 1Baylor College of Medicine, 1504 Taub Loop, Office number 5PN 71 016, 5th Floor Gastroenterology, Houston, TX 77030, USA. mgould@bcm.edu

Current Gastroenterology Reports
|September 26, 2013
PubMed
Summary
This summary is machine-generated.

Amyloidosis frequently affects the gastrointestinal tract, particularly the small intestine. Early diagnosis of gastrointestinal amyloidosis is crucial for effective patient treatment.

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Last Updated: May 7, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Published on: November 27, 2016

Performing and Processing FNA of Anterior Fat Pad for Amyloid
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Published on: October 30, 2010

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Ileectomy-induced Bile Overaccumulation in Mouse Intestine

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pathology

Background:

  • Amyloidosis is a condition characterized by the deposition of amyloid proteins in various organs.
  • The gastrointestinal tract is a common site for amyloidosis, with the small intestine being the most frequently affected region.

Purpose of the Study:

  • To highlight the common gastrointestinal manifestations of small intestinal amyloidosis.
  • To emphasize the importance of early diagnosis for appropriate therapeutic management.

Main Methods:

  • Review of clinical presentations and diagnostic considerations for gastrointestinal amyloidosis.
  • Analysis of common symptoms associated with small intestinal amyloidosis.

Main Results:

  • The small intestine is the most commonly involved gastrointestinal site in amyloidosis.
  • Key gastrointestinal manifestations include diarrhea, gastrointestinal bleeding, and obstruction.

Conclusions:

  • A high index of suspicion is essential for the early diagnosis of gastrointestinal amyloidosis.
  • Timely diagnosis facilitates tailored therapeutic strategies and improves patient outcomes.