Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response.

Anthony O Gaca1, Jessica K Kajfasz, James H Miller

  • 1Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.

Mbio
|September 26, 2013
PubMed
Summary

Basal levels of guanosine tetraphosphate (p)ppGpp are crucial for bacterial metabolism and antibiotic survival, even below stringent response thresholds. Understanding these basal pools offers new antimicrobial therapy targets.

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