Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 7, 2026

Laser Capture Microdissection of Enriched Populations of Neurons or Single Neurons for Gene Expression Analysis After Traumatic Brain Injury
13:32

Laser Capture Microdissection of Enriched Populations of Neurons or Single Neurons for Gene Expression Analysis After Traumatic Brain Injury

Published on: April 10, 2013

Transcriptome network-based method to identify genes associated with unruptured intracranial aneurysms.

L Wei1, Y J Gao, S P Wei

  • 1Department of Neurosurgery, East Hospital, Tongji University School of Medicine, Shanghai, China.

Genetics and Molecular Research : GMR
|September 26, 2013
PubMed
Summary

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Ongoing pregnancy rate with intervention and expectant therapy in patients with unexplained recurrent spontaneous abortion: a prospective multicenter cohort study].

Zhonghua fu chan ke za zhi·2025
Same author

[Modified gasless trans-subclavian approach endoscopic lateral neck dissection for treatment of papillary thyroid carcinoma: a series of 31 cases].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2023
Same author

[The tendency of invasion and progression for nasopharyngeal carcinoma].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2022
Same author

[Effects and mechanism of hydrogen peroxide pretreatment with low molarity on oxidative stress induced apoptosis of mouse bone marrow mesenchymal stem cells].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2022
Same author

[The value of renal color Doppler ultrasound in evaluating the severity and prognosis of patients with acute organophosphorus pesticide poisoning complicated by acute kidney injury].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2021
Same author

[Role of interleukin-6 in human umbilical vein endothelial cell to mesenchymal cell transformation].

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns·2021

Researchers identified key genes and regulatory networks involved in intracranial aneurysms using gene expression data. This study enhances understanding of aneurysm development and identifies potential new therapeutic targets for this serious brain condition.

Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • Intracranial aneurysms are vascular dilations within the brain, posing significant health risks.
  • The precise biological mechanisms underlying intracranial aneurysm formation remain incompletely understood.
  • Identifying genetic factors is crucial for understanding aneurysm pathogenesis.

Purpose of the Study:

  • To identify potential genes implicated in intracranial aneurysm development.
  • To construct a gene regulatory network for intracranial aneurysms.
  • To uncover novel candidate genes and transcription factors associated with the condition.

Main Methods:

  • Utilized public genome-wide gene expression profile data.
  • Performed transcriptome network analysis to identify regulatory relationships.

Related Experiment Videos

Last Updated: May 7, 2026

Laser Capture Microdissection of Enriched Populations of Neurons or Single Neurons for Gene Expression Analysis After Traumatic Brain Injury
13:32

Laser Capture Microdissection of Enriched Populations of Neurons or Single Neurons for Gene Expression Analysis After Traumatic Brain Injury

Published on: April 10, 2013

  • Cross-referenced identified genes and factors with existing literature.

    • Main Results:

    • Identified a network of transcription factors and target genes involved in intracranial aneurysms.
    • Confirmed previously known genes and transcription factors associated with the condition.
    • Discovered additional candidate genes and transcription factors potentially linked to intracranial aneurysms.

    Conclusions:

    • Transcriptome network analysis is a valuable method for identifying candidate genes in intracranial aneurysms.
    • The study provides a foundation for further research into the genetic basis of intracranial aneurysms.
    • Findings may contribute to the development of novel diagnostic and therapeutic strategies.