Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gastrointestinal immune system and its disorders.

D F Keren

    Monographs in Pathology
    |January 1, 1990
    PubMed
    Summary

    The mucosal immune response, particularly secretory IgA, is key to gut health. Future research will link this basic immunology to gastrointestinal diseases like celiac and inflammatory bowel disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    2-Mercaptoethanol treatment improves measurement of an IgMkappa M-protein by capillary electrophoresis.

    Clinical chemistry·2001
    Same author

    Introduction to the report of the consensus conference on monoclonal gammopathies.

    Archives of pathology & laboratory medicine·1999
    Same author

    Guidelines for clinical and laboratory evaluation patients with monoclonal gammopathies.

    Archives of pathology & laboratory medicine·1999
    Same author

    Procedures for the evaluation of monoclonal immunoglobulins.

    Archives of pathology & laboratory medicine·1999
    Same author

    Current practices in clinical flow cytometry. A practice survey by the American Society of Clinical Pathologists.

    American journal of clinical pathology·1999
    Same author

    Capillary zone electrophoresis in the evaluation of serum protein abnormalities.

    American journal of clinical pathology·1998

    Area of Science:

    • Gastrointestinal Immunology
    • Mucosal Immunity
    • Immunoglobulin A

    Background:

    • Significant progress has been made in understanding the basic details of the mucosal immune response over the last 15 years.
    • Secretory immunoglobulin A (IgA) is now recognized as the primary immunoglobulin produced by the mucosa.
    • Oral administration preferentially stimulates a secretory IgA response compared to parenteral administration.

    Purpose of the Study:

    • To expand the detailed understanding of the mucosal immune response.
    • To correlate fundamental immunological information with pathological processes in the gastrointestinal tract.

    Main Methods:

    • Elucidation of the cellular basis for the IgA response, highlighting its T cell dependency.
    • Utilizing monoclonal antibodies to investigate cell-mediated functions within the gut.
    • Describing alterations in the gastrointestinal immune system observed in diseases such as celiac disease and inflammatory bowel disease.

    Main Results:

    • Secretory IgA functions by binding to intraluminal microorganisms or toxins, preventing their absorption across the gut epithelium.
    • The IgA response is T cell dependent, requiring both helper T cells and switch T cells.
    • Distinct lymphocyte populations are found in different gut compartments: suppressor/cytotoxic lymphocytes in the epithelium and helper/inducer lymphocytes in the lamina propria.

    Conclusions:

    • The primary role of secretory IgA in mucosal defense is established.
    • Understanding the cellular mechanisms of the mucosal immune response is crucial.
    • Further research is needed to connect basic mucosal immunology with gastrointestinal pathologies, with some immune responses potentially being secondary to disease processes.

    Related Experiment Videos