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Metabolism of tolmetin in rat, monkey, and man
Abstract:
5-p-Carboxybenzoyl-1-methylpyrrole-2-acetic acid has been identified in the rat, monkey, and man as the major urinary metabolite of tolmetin, a new nonsteroidal anti-inflammatory agent. Conjugation of tolmetin, a major mode of disposition in man and monkey, was not observed in the rat.
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