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Updated: May 7, 2026

Manual Segmentation of the Human Choroid Plexus Using Brain MRI

Manual Segmentation of the Human Choroid Plexus Using Brain MRI

Published on: December 15, 2023

Choroidal volume variations during childhood.

Chiara Mapelli¹, Laura Dell'Arti, Giulio Barteselli

¹University of Milan, Department of Clinical Sciences and Community Health, Milan, Italy.

Investigative Ophthalmology & Visual Science

|September 26, 2013

Summary

This summary is machine-generated.

Choroidal volume (CV) increases with age in children but decreases with longer axial length (AXL). This study in healthy children suggests the choroid grows throughout childhood, with potential sex differences in CV.

Keywords:

choroidal thickness choroidal volume enhanced depth imaging optical coherence tomography

Related Experiment Videos

Last Updated: May 7, 2026

Manual Segmentation of the Human Choroid Plexus Using Brain MRI

Manual Segmentation of the Human Choroid Plexus Using Brain MRI

Published on: December 15, 2023

Area of Science:

Ophthalmology
Pediatric Ophthalmology
Optical Coherence Tomography

Background:

Choroidal volume (CV) is a key ocular parameter.
Understanding CV development in children is crucial for eye health.
Enhanced depth imaging optical coherence tomography (EDI-OCT) allows detailed choroidal analysis.

Purpose of the Study:

To analyze choroidal volume (CV) variations in healthy children.
To evaluate the association of CV with age, axial length (AXL), sex, weight, and height.

Main Methods:

Retrospective review of EDI-OCT scans from 52 healthy children.
Manual segmentation of the choroid was performed.
Ocular examination and axial length (AXL) measurements were obtained.

Main Results:

Mean CV was 0.263 mm³ (foveal) and 8.545 mm³ (total ETDRS grid).
CV showed a significant negative correlation with AXL and a positive correlation with age.
CV increased with age and decreased with AXL; a trend for higher CV in females was observed.

Conclusions:

Choroidal volume (CV) increases with age and decreases with axial length (AXL) during childhood.
These findings support progressive choroidal growth in children.
Potential intersexual differences in CV warrant further investigation.