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Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively

Yanchun Du1, Lin Deng, Yan Li

  • 1The First Hospital of Xiamen University, Xiamen 361003, China.

Clinical & Developmental Immunology
|September 26, 2013
PubMed
Abstract

Insights

PERP expression is decreased in rheumatoid arthritis (RA) patients, while IL-17 is increased. PERP may be a therapeutic target for RA by regulating IL-17.

Area of Science:

  • Immunology
  • Molecular Biology
  • Rheumatology

Background:

  • PERP (p53 apoptosis effector) plays a role in p53-mediated apoptosis.
  • Its function in peripheral blood mononuclear cells (PBMCs) of rheumatoid arthritis (RA) patients is not well understood.

Purpose of the Study:

  • To investigate PERP expression levels in PBMCs from RA patients and healthy controls.
  • To analyze the role of PERP in RA pathogenesis, particularly its relationship with IL-17 and disease activity.

Main Methods:

  • Real-time PCR was used to measure mRNA expression of PERP and IL-17 in PBMCs.
  • Correlations between PERP levels, IL-17, and clinical disease parameters (DAS28, RF, CRP, ESR, Anti-CCP, ANA) were analyzed.

Main Results:

  • PERP mRNA levels were significantly decreased in RA patients compared to healthy controls.
  • IL-17 mRNA levels were significantly increased in RA patients.
  • PERP expression negatively correlated with IL-17, DAS28, RF, CRP, and ESR.

Conclusions:

  • PERP expression is altered in RA PBMCs.
  • PERP may contribute to RA pathogenesis by influencing IL-17 levels.
  • PERP represents a potential therapeutic target for RA.

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