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Quinine-induced hearing loss.

F W Nielsen-Abbring1, R M Perenboom, R J van der Hulst

  • 1ENT Department, University of Amsterdam, The Netherlands.

ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties
|January 1, 1990
PubMed
Summary

Quinine therapy for malaria can cause reversible sensorineural hearing loss. This study highlights the ototoxicity of quinine, particularly with increasing malaria resistance to other drugs.

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Area of Science:

  • Ototoxicology
  • Pharmacology
  • Infectious Diseases

Background:

  • Sensorineural hearing loss from quinine therapy for malaria is a known but under-researched complication.
  • Increasing resistance to chloroquine necessitates greater reliance on quinine for treating falciparum malaria.
  • Ultrahigh frequency audiometry (up to 20 kHz) is a precise method for assessing quinine-induced ototoxicity.

Observation:

  • A case study of a 29-year-old man with falciparum malaria treated with quinine is presented.
  • The patient experienced reversible hearing loss as a consequence of the quinine therapy.

Findings:

  • Quinine therapy can lead to temporary, yet significant, sensorineural hearing impairment.
  • The ototoxic effects of quinine are detectable and potentially reversible.

Implications:

  • This case underscores the importance of monitoring hearing function in patients undergoing quinine treatment for malaria.
  • Further research into quinine's ototoxicity is warranted, especially given its continued use in malaria management.
  • Audiological monitoring may help mitigate hearing loss complications in malaria patients.

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