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Morphology-based plasmonic nanoparticle sensors: controlling etching kinetics with target-responsive permeability

Brian Malile¹, Jennifer I L Chen

¹Department of Chemistry, York University , 4700 Keele Street, Toronto, Ontario Canada M3J 1P3.

Journal of the American Chemical Society

|September 27, 2013

Summary

This study introduces a novel label-free sensor using nanoparticle shape changes for detection. Analyte binding controls etchant diffusion, altering nanoparticle morphology and color for biodiagnostics.

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Area of Science:

Nanotechnology
Materials Science
Analytical Chemistry

Background:

Plasmonic nanoparticles are widely used in sensing applications.
Conventional sensors often require labels and rely on interparticle interactions.
Controlling nanoparticle morphology offers a new sensing paradigm.

Purpose of the Study:

To develop a facile, label-free sensing platform based on plasmonic nanoparticle morphological changes.
To utilize stimulus-responsive polyelectrolyte-aptamer thin films for controlled etchant diffusion.
To establish a colorimetric readout dependent on analyte concentration.

Main Methods:

Fabrication of a sensing film incorporating stimulus-responsive polyelectrolyte-aptamer.
Controlled diffusion of etchants to modify plasmonic nanoparticle size and shape.

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Colorimetric analysis of nanoparticle morphological changes correlated with analyte binding.

Main Results:

Demonstrated that analyte binding modulates etchant diffusion rates.
Showcased a direct correlation between analyte concentration and nanoparticle morphological changes.
Observed a distinct colorimetric response proportional to the extent of nanoparticle alteration.

Conclusions:

The developed platform offers a novel, label-free detection mechanism for analytes.
The sensor design is independent of interparticle plasmon coupling, simplifying the system.
This approach enables the creation of low-cost, portable chip-based sensors for biodiagnostics and field analysis.