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Related Experiment Video

Updated: May 7, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Review: dermatitis herpetiformis.

Fernanda Berti Rocha Mendes¹, Adaucto Hissa-Elian, Marilda Aparecida Milanez Morgado de Abreu

¹Presidente Prudente Regional Hospital, University of Oeste Paulista, Presidente Prudente(SP),Brazil.

Anais Brasileiros De Dermatologia

|September 27, 2013

Summary

Dermatitis herpetiformis (DH) is an IgA-mediated skin disease linked to celiac disease. Treatment involves dapsone and a strict gluten-free diet to manage symptoms.

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Area of Science:

Immunodermatology
Gastroenterology
Genetics

Background:

Dermatitis herpetiformis (DH), also known as Duhring-Brocq disease, is a chronic blistering skin condition.
It presents with intense itching, burning, erythematous papules, urticarial plaques, and tense blisters.
DH is strongly associated with specific HLA genotypes (HLA DR3, HLA DQw2) and IgA deposits in the skin.

Purpose of the Study:

To elucidate the immunological and genetic links between Dermatitis herpetiformis and celiac disease.
To highlight the common diagnostic markers and autoimmune comorbidities.
To outline the established treatment protocols for DH.

Main Methods:

Review of existing literature on DH pathogenesis, genetics, and immunology.
Analysis of serological markers common to DH and celiac disease.
Examination of the association with other autoimmune disorders.

Main Results:

DH is an IgA-mediated disease with granular IgA deposits in the dermal papilla.
Strong genetic association with HLA DR3 and HLA DQw2.
Shared antibodies (antiendomysium, antireticulina, antigliadin, transglutaminase) and increased zonulin production with celiac disease.
Increased prevalence of other autoimmune diseases like thyroid disease and type 1 diabetes.

Conclusions:

Dermatitis herpetiformis shares significant immunological and genetic links with adult celiac disease.
Diagnosis is supported by specific autoantibodies and HLA typing.
Management requires dapsone and a strict gluten-free diet, alongside monitoring for associated autoimmune conditions.