Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The external carotid artery: A multimodal anatomical synthesis of variants and surgical corridors, with a proposed CTA reporting framework.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2026

Same author

Artificial Intelligence in Orofacial Pain: Diagnostic and Predictive Performance Across Machine Learning and Deep Learning Models.

Diagnostics (Basel, Switzerland)·2026

Same author

Are tomorrow's dentists ready for a sustainable future? Insights from a European student survey.

Frontiers in dental medicine·2026

Same author

Low-Level Laser Therapy for Gingival Inflammation in Children and Adolescents: A Narrative Review Based on In Vitro, In Vivo and Clinical Studies.

Healthcare (Basel, Switzerland)·2026

Same author

Administrative Perspectives on Digital Workflow Transformation and Artificial Intelligence Implementation in Dental Clinics.

Dentistry journal·2026

Same author

Immersive Technologies in Dental Education: Global Adoption Patterns From a 2025 Survey.

Journal of dental education·2026

Search research articles

Related Experiment Video

Updated: May 7, 2026

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Published on: May 17, 2024

Dental pulp as a stem cell reservoir.

Andreea Cristiana Didilescu¹, M C Rusu, G Nini

¹Discipline of Anatomy, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; anatomon@gmail.com.

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie

|September 27, 2013

Summary

Adult stem cells from dental pulp play roles in tissue regeneration. This review examines their origins, immunophenotype, and niche characteristics for potential clinical applications.

More Related Videos

Primary Culture of Dental Pulp Stem Cells

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Related Experiment Videos

Last Updated: May 7, 2026

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Published on: May 17, 2024

Primary Culture of Dental Pulp Stem Cells

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Area of Science:

Biomedical Science
Regenerative Medicine
Dental Research

Background:

Post-natal dental pulp harbors stem cell niches crucial for tissue regeneration.
Three distinct types of adult stem cells have been successfully isolated from dental pulp.
Understanding these cells is vital for assessing their clinical potential.

Purpose of the Study:

To review the origins of adult stem cells found in dental pulp.
To analyze the immunophenotype of these dental pulp stem cells.
To discuss the specific characteristics of interstitial cells within stem cell niches.

Main Methods:

Literature review of existing studies on dental pulp stem cells.
Analysis of research data on cell origins and immunophenotypic markers.
Discussion of interstitial cell properties within stem cell niches.

Main Results:

Information on the presence and regenerative roles of dental pulp stem cell niches is abundant.
Established protocols exist for isolating three types of adult stem cells from dental pulp.
Ongoing research focuses on detailed characterization for clinical translation.

Conclusions:

Dental pulp stem cells offer significant promise for regenerative therapies.
Further investigation into their origins and immunophenotype is essential.
Clarifying the role of interstitial cells will enhance therapeutic strategies.