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Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
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Differential roles of postsynaptic density-93 isoforms in regulating synaptic transmission

Juliane M Krüger1, Plinio D Favaro, Mingna Liu

  • 1European Neuroscience Institute, 37077 Göttingen, Germany, Göttingen Graduate School for Neurosciences and Molecular Biosciences, 37077 Göttingen, Germany, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany, International Max Planck Research School for Neuroscience, 37077 Göttingen, Germany, Bioanalytics, Department of Clinical Chemistry, 37075 Göttingen, Germany, and Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|September 27, 2013
PubMed
Summary

The scaffolding protein PSD-93, with its six isoforms, is crucial for maintaining excitatory synaptic transmission strength. Different PSD-93 isoforms fine-tune signaling to meet varying synaptic demands during development.

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