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Alteration of liver function due to H1N1 infection: a case report

Ahmed H Alhammadi1, Mohamed A Hendaus, Anas A Kayoum

  • 1Department of Pediatrics, Section of General Pediatrics, Hamad Medical Corporation, Doha, Qatar.

Clinical and Experimental Gastroenterology
|September 27, 2013
PubMed

Insights

This study highlights a rare case of H1N1 virus infection causing abnormal liver function in a child. Prompt treatment with oseltamivir led to rapid improvement in liver tests alongside respiratory symptoms.

Area of Science:

  • Pediatrics
  • Virology
  • Hepatology

Background:

  • Influenza A H1N1 virus primarily targets the respiratory system.
  • Healthcare providers often focus on respiratory complications, potentially missing multi-organ effects.
  • Pediatric H1N1 cases require comprehensive evaluation for systemic involvement.

Observation:

  • A child presented with respiratory illness due to H1N1 virus infection.
  • Marked elevation in liver function tests was observed concurrently with respiratory symptoms.
  • This suggests a potential link between H1N1 and hepatic dysfunction in pediatric patients.

Findings:

  • The H1N1 infection was associated with significant liver enzyme elevation.
  • Treatment with oseltamivir resulted in a dramatic decrease in liver function test levels within 72 hours.
  • This indicates a possible direct or indirect impact of H1N1 on liver function.

Implications:

  • H1N1 virus may cause non-respiratory complications, including liver dysfunction, in children.
  • Early recognition and treatment of H1N1 are crucial for managing systemic effects.
  • Further research is warranted to understand the mechanisms of H1N1-induced liver injury.

Keywords:
H1N1 subtype influenza A virushepatic function impairment

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