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Related Experiment Video

Updated: May 7, 2026

Mosaic Analysis of Gene Function in Postnatal Mouse Brain Development by Using Virus-based Cre Recombination
07:42

Mosaic Analysis of Gene Function in Postnatal Mouse Brain Development by Using Virus-based Cre Recombination

Published on: August 1, 2011

Specialization of gene expression during mouse brain development.

Noa Liscovitch1, Gal Chechik

  • 1Gonda Multidisiplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.

Plos Computational Biology
|September 27, 2013
PubMed
Summary
This summary is machine-generated.

Brain gene expression initially becomes less specialized during early development, then increasingly specialized after birth, particularly in the cerebellum. This developmental pattern differs between mice and humans in key brain regions.

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Related Experiment Videos

Last Updated: May 7, 2026

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07:42

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Published on: August 1, 2011

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Published on: March 8, 2024

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08:06

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Published on: February 15, 2021

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Transcriptomics

Background:

  • Brain development involves dynamic changes in gene expression, shaping functional specialization of brain regions.
  • Understanding the temporal dynamics of transcriptional specialization is crucial for deciphering brain development and function.

Purpose of the Study:

  • To quantify the functional specialization of brain regions during mouse development using gene expression analysis.
  • To investigate the temporal dynamics of transcriptional specialization from early development through post-natal stages.

Main Methods:

  • Analyzed gene expression across the entire developing mouse brain using in situ hybridization.
  • Quantified regional specialization by measuring gene expression patterns at different developmental time points.

Main Results:

  • Transcriptional specialization decreases during early brain regionalization, reaching a nadir around birth (neurotypic period).
  • This early decrease is brain-wide and linked to circuitry construction processes.
  • Post-natal development sees a rise in regional specialization, driven by plasticity and neural activity genes, notably in the cerebellum.

Conclusions:

  • Mouse brain development exhibits an inverse relationship between anatomical and transcriptional regionalization in early stages.
  • Post-natal cerebellar specialization is conserved in humans, but thalamic and cortical regionalization patterns diverge significantly from mice.
  • These findings highlight species-specific differences in the developmental trajectories of brain gene expression.