Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 7, 2026

Implantation and Recording of Wireless Electroretinogram and Visual Evoked Potential in Conscious Rats
11:22

Implantation and Recording of Wireless Electroretinogram and Visual Evoked Potential in Conscious Rats

Published on: June 29, 2016

Conscious wireless electroretinogram and visual evoked potentials in rats.

Jason Charng1, Christine T Nguyen, Zheng He

  • 1Department of Optometry & Vision Sciences, University of Melbourne, Victoria, Australia.

Plos One
|September 27, 2013
PubMed
Summary

Researchers developed a new platform for conscious wireless recording of electroretinograms (ERG) and visual evoked potentials (VEP) in rats. This method avoids anesthesia, providing more accurate data for visual pathway studies and drug assessments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of Confocal Multispectral Imaging Using a Common Commercial Device and Application in a Healthy Aging Mouse Model.

Investigative ophthalmology & visual science·2026
Same author

Frequency, Severity and Ergonomic Awareness of Work-Related Musculoskeletal Disorders Among Australian Optometrists: A Cross-Sectional Survey.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)·2026
Same author

Optometrists' practice of falls prevention care for community dwelling older adults: A mixed methods systematic review.

BMC geriatrics·2026
Same author

"Getting to diagnosis was an absolute nightmare": survey insights about the lived experience of spinal CSF leak in Australia and Aotearoa New Zealand.

Journal of neurology·2026
Same author

Evaluation of CRISPR/CasRx-Mediated VEGF mRNA Knockdown in Mouse Retina.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Response of the Rat Eye to Acute and Chronic Optic Nerve Pressure Modifications.

Investigative ophthalmology & visual science·2026

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Biomedical Engineering

Background:

  • Electroretinogram (ERG) and visual evoked potential (VEP) are crucial in vivo tools for assessing the visual pathway's integrity.
  • Current preclinical recordings under anesthesia introduce physiological alterations, contaminating electrophysiological responses.
  • Anesthesia complicates longitudinal studies and accurate drug effect assessments in visual pathway research.

Purpose of the Study:

  • To develop and validate a conscious wireless recording platform for ERG and VEP in preclinical models (rats).
  • To demonstrate the impact of anesthesia on electrophysiology recordings.
  • To establish a reliable method for longitudinal visual pathway assessment and drug effect evaluation in conscious subjects.

Main Methods:

More Related Videos

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats
10:30

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats

Published on: July 1, 2016

Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning
06:34

Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning

Published on: June 9, 2015

Related Experiment Videos

Last Updated: May 7, 2026

Implantation and Recording of Wireless Electroretinogram and Visual Evoked Potential in Conscious Rats
11:22

Implantation and Recording of Wireless Electroretinogram and Visual Evoked Potential in Conscious Rats

Published on: June 29, 2016

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats
10:30

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats

Published on: July 1, 2016

Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning
06:34

Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning

Published on: June 9, 2015

  • A novel surgical technique was employed for chronic implantation of subconjunctival electrodes (eye) and epidural electrodes (visual cortex) in rats.
  • Wireless technology was integrated for continuous data acquisition.
  • ERG and VEP signals were recorded from conscious, freely moving rats over a period of at least one month.

    • Main Results:

    • Stable and repeatable conscious ERG and VEP signals were successfully recorded for over one month.
    • Direct comparison demonstrated that anesthesia significantly alters electrophysiology recordings compared to conscious recordings.
    • The developed platform provides uncontaminated electrophysiological data, unaffected by anesthetic agents.

    Conclusions:

    • A conscious wireless ERG and VEP recording platform in rats enables reliable, long-term electrophysiological measurements.
    • Eliminating anesthesia improves the accuracy of visual pathway assessments and longitudinal studies.
    • This platform enhances the eye's utility as a biomarker for central nervous system activity and drug effects.