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Related Experiment Video

Updated: May 7, 2026

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

Published on: February 3, 2017

Eiger triggers death from afar.

Ginés Morata¹, Salvador C Herrera

¹is at the Centro de Biología Molecular Severo Ochoa , Universidad Autónoma de Madrid , Madrid , Spain gmorata@cbm.uam.es.

|September 27, 2013

Summary

This summary is machine-generated.

Cells undergoing programmed cell death release signals that can induce death in distant cells. This intercellular communication highlights a novel mechanism in cell death signaling pathways.

Keywords:

D. melanogaster JNK pathway Mouse TNF apoptosis cell death hair follicle cycle signaling by apoptotic cells

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Last Updated: May 7, 2026

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

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Published on: February 3, 2017

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

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Published on: March 16, 2020

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Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Programmed cell death, or apoptosis, is a fundamental biological process.
Cellular signaling plays a critical role in regulating apoptosis.
The mechanisms by which dying cells influence remote cells are not fully understood.

Purpose of the Study:

To investigate the role of signals released by dying cells.
To determine if these signals can induce cell death in non-adjacent cells.
To elucidate the mechanisms of intercellular communication in programmed cell death.

Main Methods:

Utilizing cell culture models to induce programmed cell death.
Employing techniques to collect and transfer signaling molecules released by dying cells.
Assessing the impact of transferred signals on recipient cell viability and death pathways.

Main Results:

Signals released from cells undergoing programmed cell death were identified.
These signals demonstrated the capacity to trigger cell death in recipient cells located remotely.
Evidence suggests a signaling cascade initiated by external factors from dying cells.

Conclusions:

Dying cells can actively propagate cell death signals to distant cells.
This intercellular communication represents a significant mechanism in regulating tissue homeostasis and organismal development.
Further research into these signals could reveal new therapeutic targets for diseases involving aberrant cell death.