Targeted therapy for breast cancer prevention
Petra den Hollander1, Michelle I Savage, Powel H Brown
1Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center , Houston, TX , USA.
Frontiers in Oncology
|September 27, 2013
Summary
Targeted drugs like selective estrogen receptor modulators and aromatase inhibitors show promise in preventing estrogen receptor-positive breast cancer. Research is expanding to find new preventive therapies for HER2-positive and triple-negative breast cancer.
Area of Science:
- Oncology
- Pharmacology
- Cancer Prevention
Background:
- Molecularly targeted drugs are being developed for breast cancer treatment and prevention.
- Selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) target estrogen receptor (ER)-positive pathways.
- Current preventive strategies are limited to ER-positive breast cancer.
Purpose of the Study:
- To review current breast cancer preventive drugs.
- To discuss research progress in identifying novel preventive agents for all breast cancer subtypes.
- To highlight the need for therapies targeting HER2-positive and triple-negative breast cancer (TNBC).
Main Methods:
- Review of preclinical and clinical studies on targeted breast cancer preventive agents.
- Analysis of drugs targeting ER-positive, HER2-positive, and TNBC.
- Discussion of agents like SERMs, AIs, anti-HER2 therapies, PARP inhibitors, vitamin D, and rexinoids.
Main Results:
- Tamoxifen and raloxifene reduce breast cancer risk.
- Aromatase inhibitors show promise for preventing ER-positive breast cancer.
- Research is ongoing for HER2-positive and TNBC preventive therapies.
Conclusions:
- Targeted therapies offer new avenues for breast cancer prevention.
- Further research is crucial to develop effective preventive strategies for all breast cancer subtypes.
- Identifying preventive agents for HER2-positive and TNBC is a key focus.
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