Chemokine receptors in psoriasis
Tej Pratap Singh1, Chang Hoon Lee, Joshua M Farber
1National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Molecular Immunology, Inflammation Biology Section , Bethesda, MD 20892 , USA jfarber@niaid.nih.gov.
Expert Opinion on Therapeutic Targets
|September 28, 2013
Summary
This review explores the chemokine system
Area of Science:
- Immunology
- Dermatology
Background:
- Psoriasis is a common immune-mediated skin disease.
- Leukocyte infiltration is central to psoriasis pathogenesis.
- Chemokines and their receptors regulate leukocyte trafficking in skin.
Purpose of the Study:
- To review the role of the chemokine system in psoriasis.
- To identify therapeutic opportunities by targeting chemokines.
- To highlight the IL-23/IL-17/IL-22 cytokine axis in disease.
Main Methods:
- Literature review of leukocyte subsets in psoriasis.
- Focus on chemokine receptors mediating leukocyte trafficking.
- Discussion of the IL-23/IL-17/IL-22 cytokine axis.
Main Results:
- Chemokine receptors are key targets for leukocyte trafficking in psoriasis.
- The IL-23/IL-17/IL-22 pathway is significant in disease development.
- Current therapies often target cytokines with broad functions.
Conclusions:
- Targeting chemokine receptors with small molecules offers potential for targeted anti-inflammatory therapy.
- Limited success of chemokine receptor antagonists may stem from system redundancy and incomplete understanding of pathogenesis.
- Further research into chemokine system roles is crucial for effective psoriasis treatment.
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