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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Topographic optic disc changes after successful trabeculectomy evaluated using spectral domain optical coherence
Andrea Russo1, Andreas Katsanos, Ivano Riva
11 Centre for the Study of Glaucoma, University of Brescia , Brescia, Italy .
Summary
Trabeculectomy surgery significantly lowers intraocular pressure in open-angle glaucoma patients. This reduction causes temporary optic disc changes, which are no longer apparent one year post-surgery.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Surgical Outcomes
Background:
- Open-angle glaucoma (OAG) is a leading cause of irreversible blindness.
- Surgical intervention, like trabeculectomy, is often necessary to reduce intraocular pressure (IOP) in advanced cases.
- Understanding the impact of IOP reduction on optic disc topography is crucial for managing glaucoma progression.
Purpose of the Study:
- To evaluate the topographic changes of the optic disc following surgical reduction of intraocular pressure (IOP) in adults diagnosed with open-angle glaucoma (OAG).
Main Methods:
- Optical coherence tomography (OCT) was used to image the optic discs of patients with advanced OAG or exfoliation glaucoma before and at 1 week, 1 month, and 1 year after trabeculectomy.
- Key metrics, including maximum cup depth (MCD) and average cup depth (ACD), were calculated to assess optic disc topography.
Main Results:
- Trabeculectomy led to a significant IOP reduction from baseline (22.1 mmHg) to 1 year post-surgery (11.5 mmHg) (P<0.001).
- A significant decrease in average cup depth (ACD) was observed at 1 week (P<0.001) and 1 month (P=0.007) post-surgery, but this was not sustained at 1 year.
- Maximum cup depth (MCD) also showed a significant decrease at 1 week (P=0.029) and 1 month (P=0.047), with no significant change at the 1-year follow-up.
Conclusions:
- Surgical IOP reduction via trabeculectomy in advanced OAG induces measurable topographic optic disc changes.
- These optic disc alterations were transient, diminishing over time and becoming undetectable by the 1-year mark post-surgery.
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