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Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Cleavage and Blastulation01:33

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...

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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging
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Gastrulation: cell polarity comes full circle.

Miranda V Hunter1, Rodrigo Fernandez-Gonzalez

  • 1Department of Cell and Systems Biology, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.

Current Biology : CB
|September 28, 2013
PubMed
Summary
This summary is machine-generated.

Embryonic tissue bending relies on cell shape changes. A new study identifies key molecules and their locations during mesoderm internalization in Drosophila.

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Area of Science:

  • Developmental biology
  • Cell biology
  • Genetics

Background:

  • Embryonic development involves complex tissue morphogenesis.
  • Cell shape dynamics are crucial for tissue bending and internalization.
  • Mesoderm internalization is a fundamental developmental process.

Purpose of the Study:

  • To identify molecules regulating mesoderm internalization in Drosophila.
  • To characterize the spatial localization of these molecules during development.

Main Methods:

  • Utilized Drosophila melanogaster as a model organism.
  • Employed advanced imaging techniques to observe cellular processes.
  • Molecular biology techniques to identify key proteins and their functions.

Main Results:

  • Detailed the molecular players involved in mesoderm internalization.
  • Revealed a specific spatial localization pattern for these molecules.
  • Demonstrated the necessity of these molecules for proper tissue bending.

Conclusions:

  • The study elucidates novel molecular mechanisms governing embryonic tissue morphogenesis.
  • Understanding these processes provides insights into conserved developmental pathways.
  • Findings contribute to the field of developmental cell biology.