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Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
[Tubular renal acidosis].
A Seidowsky1, L Moulonguet-Doleris2, T Hanslik3
1Université Versailles Saint-Quentin-en-Yvelines, 78000 Versailles, France; Service de médecine interne, hôpital Ambroise-Paré, AP-HP, 92104 Boulogne-Billancourt cedex, France; Service de néphrologie, hôpital Ambroise-Paré, AP-HP, 92104 Boulogne-Billancourt cedex, France.
La Revue De Medecine Interne
|September 28, 2013
Summary
Renal tubular acidosis (RTAs) are metabolic disorders affecting kidney tubules, leading to acid buildup. Treatment involves alkalinization to manage conditions like type I, II, and IV RTAs.
Area of Science:
- Nephrology
- Internal Medicine
- Pediatrics
Background:
- Renal tubular acidosis (RTAs) encompass metabolic disorders characterized by metabolic acidosis and a normal plasma anion gap.
- These conditions arise from impaired kidney tubule function, affecting acid-base balance.
Observation:
- Three primary forms exist: proximal RTA (type II) due to bicarbonate reabsorption failure, and distal RTA (type I and IV) from impaired acid excretion.
- Type IV RTA is frequently linked to hypoaldosteronism, while type I is associated with hypokalemia and type IV with hyperkalemia.
Findings:
- RTA type II results from proximal tubule dysfunction in bicarbonate reabsorption.
- Distal RTA (types I and IV) involves the inability to excrete daily acid loads, potentially causing hypokalemia (type I) or hyperkalemia (type IV).
Implications:
- Complications include nephrocalcinosis and obstructive nephrolithiasis.
- Alkalinization therapy is the fundamental treatment approach for all RTA types.
- Understanding RTA subtypes is crucial for accurate diagnosis and targeted management.
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