Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epithelioid Fibrous Histiocytoma With Giant Cells and VCL-Anaplastic Lymphoma Kinase Fusion: A Diagnostic Challenge.

The American Journal of dermatopathology·2026
Same author

Previously unrecognised gene fusions across diverse solid tumours identified by anchored multiplex RNA sequencing.

Journal of clinical pathology·2026
Same author

Identification of NTRK3 fusions in plaque-like CD34-positive dermal fibroma.

Histopathology·2026
Same author

NF1 Loss Remodels Tumor Niches for Immune Evasion.

bioRxiv : the preprint server for biology·2026
Same author

Population Analysis and Immunologic Landscape of Melanoma in People Living with HIV.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: May 7, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Primary cutaneous carcinosarcoma: insights into its clonal origin and mutational pattern expression analysis through

Alberto E Paniz Mondolfi1, George Jour, Matthew Johnson

  • 1Baylor College of Medicine, Division of Investigative and Molecular Pathology, Department of Pathology and Immunology, Houston, TX 77030, USA; Fundación Jacinto Convit (SAIB/IVSS) & Universidad de Los Andes (ULA), Departments of Biochemistry and Dermatopathology, Caracas, Venezuela 1010-A.

Human Pathology
|September 28, 2013
PubMed
Summary

Primary cutaneous carcinosarcoma, a rare cancer with epithelial and sarcomatous parts, likely originates from a single progenitor cell. Genetic analysis revealed identical TP53 mutations in both tumor components, supporting a common clonal origin.

Keywords:
Biphenotypic tumorsCancer stem cellsCarcinosarcomaCutaneousMutationNext-generation sequencingTP53Tumorigenesis

More Related Videos

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Related Experiment Videos

Last Updated: May 7, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Area of Science:

  • Oncology
  • Dermatopathology
  • Molecular Pathology

Background:

  • Primary cutaneous carcinosarcoma is a rare biphenotypic neoplasm with poorly understood origins.
  • It is postulated to arise from progenitor cells differentiating into epithelial and sarcomatous components.

Observation:

  • Histological, ultrastructural, and immunohistochemical analyses were performed on a cutaneous carcinosarcoma case.
  • Transitional cells showed progenitor cell markers (K19, c-kit, CD34, Bcl-2), and both components expressed EpCAM.
  • Ultrastructural examination revealed cells with features of both epithelial and mesenchymal differentiation.

Findings:

  • Laser capture microdissection separated epithelial and sarcomatous components for next-generation sequencing.
  • Identical TP53 point mutations in exon 5 were found in both tumor components.
  • These mutations correlated with p53 protein expression, suggesting a common genetic alteration.

Implications:

  • The findings strongly suggest a common clonal origin for the distinct epithelial and sarcomatous elements of cutaneous carcinosarcoma.
  • This research provides insights into the pathogenesis of this rare tumor.
  • Understanding the clonal origin may inform future diagnostic and therapeutic strategies.