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Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
Published on: April 7, 2023
Future for probiotic science in functional food and dietary supplement development
1Microbial Ecology, Nutrition & Health Research Group, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain.
Current Opinion in Clinical Nutrition and Metabolic Care
|September 28, 2013
Summary
Next-generation probiotics, informed by gut microbiome research, show promise for health. Further human studies are needed to confirm their effectiveness in personalized nutrition and disease prevention.
Area of Science:
- Probiotic science
- Gut microbiome research
- Human health and nutrition
Background:
- The gut microbiome plays a crucial role in human physiology, influencing health and disease.
- Advances in sequencing technologies enhance our understanding of the gut microbiota's complexity.
- Modulating the gut ecosystem holds potential for maintaining health and reducing disease risk.
Purpose of the Study:
- To update on probiotic science, from classical approaches to next-generation probiotics.
- To align probiotic development with evolving insights into the gut microbiome.
- To explore the role of the gut microbiome in human health.
Main Methods:
- Review of classical and next-generation probiotic research.
- Analysis of high-throughput and next-generation sequencing data in epidemiological studies.
- Evaluation of preclinical trials for novel probiotic candidates.
Main Results:
- Classical probiotics show limited evidence for microbiome-mediated effects in humans.
- Next-generation probiotic candidates (e.g., Clostridia, F. prausnitzii, A. muciniphila) show promise in preclinical studies for inflammatory and diet-related disorders.
- The effectiveness of nonconventional indigenous gut bacteria in humans requires further investigation.
Conclusions:
- Understanding indigenous gut bacteria and their interactions is key for selecting effective probiotic strains.
- Integrated dietary strategies can optimize gut microbiome modulation for improved nutrition and clinical practice.
- Further research is needed to translate preclinical findings into clinical applications and personalized nutrition.
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