Related Experiment Video
Updated: May 7, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Follicular variant of papillary carcinoma presenting as a hyperfunctioning thyroid nodule
Filip Gabalec1, Ioannis Svilias, Ivana Plasilova
1Departments of *Internal Medicine IV †Pediatrics ‡The Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital in Hradec Kralove, Hradec Králové, Czech Republic.
Abstract:
In this study, we describe a case of papillary carcinoma in a 15-year-old girl who presented with a hyperfunctioning (hot) thyroid nodule and discuss it in the context of current management guidelines for patients with thyroid nodules. In adults, hot nodules rarely require cytologic or histologic evaluation, and hyperthyroidism is often treated with radioiodine (131I). However, in children and adolescents, the malignancy rate for nodules (both cold and hot) is higher and surgery is often necessary. Surgery may serve as a therapy, as well as a diagnostic tool, to treat hot nodules in children and adolescents.
Related Concept Videos
Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Graves Disease II: Pathophysiology
Goiter
Graves' Disease I: Introduction
