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Updated: May 7, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Severe leukemoid reaction in a preterm infant with congenital cytomegalovirus infection
Dilek U Isik1, Ozge Aydemir, Yusuf Kale
1*Neonatal Intensive Care Unit, Department of Neonatology, Etlik Zübeyde Hanim Women's Health Teaching and Research Hospital †Department of Pathology, Dr Sami Ulus Maternity and Children's Hospital, Ankara, Turkey.
Abstract:
Leukemoid reaction, defined as a total leukocyte count of >50,000/mm, is most commonly related to antenatal administration of steroids, infections, and transient myeloproliferative disorder of Down syndrome in newborns. Atypical presentations of viral infections can be a diagnostic challenge in the newborn period. Cytomegalovirus (CMV) infection causes a multisystem disease, and symptomatic infants generally present with intrauterine growth restriction, hepatosplenomegaly, cholestasis, rash, thrombocytopenia, and microcephaly. We present a case of a preterm infant with severe myeloid leukemoid reaction (leukocyte count >100,000/mm) at birth who was diagnosed with congenital CMV infection on the basis of CMV polymerase chain reaction results after the appearance of cholestasis, blueberry muffin rash, and hepatosplenomegaly.
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