Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidental DWI-Positive Lesions in 2 Cohorts of CAA and CADASIL: Prevalence, Distribution, and Associations With Clinical Variables.

Neurology·2026
Same author

Differential associations of plasma biomarkers with Alzheimer's disease and small vessel disease: A multimodal imaging study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Expanding the Clinicoradiologic Phenotype of the <i>CTSA</i>-Associated Small Vessel Disease CARASAL: A Comparison With CADASIL.

Neurology. Genetics·2026
Same author

Genome-wide study identifies a locus associated with atopic dermatitis severity in a canine model.

The Journal of investigative dermatology·2026
Same author

Critical and non-critical connections not differently associated with either Alzheimer's disease or vascular pathologies.

medRxiv : the preprint server for health sciences·2026
Same author

Brain-derived tau for monitoring brain injury in acute ischemic stroke.

Science translational medicine·2026

Related Experiment Video

Updated: May 7, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Anterior temporal lobe degeneration produces widespread network-driven dysfunction.

Christine C Guo1, Maria Luisa Gorno-Tempini, Benno Gesierich

  • 11. Memory and Ageing Centre, Department of Neurology, University of California, San Francisco, USA.

Brain : a Journal of Neurology
|September 28, 2013
PubMed
Summary

Semantic memory relies on a hub in the anterior temporal lobe (ATL) interacting with distributed brain regions. Degeneration in the ATL impacts connected areas, affecting semantic knowledge processing.

Keywords:
anterior temporal lobecognitionfunctional neuroimagingsemantic dementiasemantics

More Related Videos

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
12:30

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

Published on: July 2, 2014

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Related Experiment Videos

Last Updated: May 7, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
12:30

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

Published on: July 2, 2014

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • The neural basis of semantic memory is debated, with models including 'distributed-only' and 'anterior temporal lobe (ATL) hub' theories.
  • Semantic variant primary progressive aphasia (svPPA) observations suggest the ATL acts as an amodal hub linking modality-specific regions.

Purpose of the Study:

  • To investigate the intrinsic functional interactions between the ATL hub and sensory regions in semantic memory.
  • To provide neurophysiological evidence for the ATL hub theory of semantic knowledge representation.

Main Methods:

  • A multimodal brain imaging study was conducted on healthy subjects and patients with svPPA.
  • Functional connectivity and physiological integrity of brain regions supporting semantic knowledge were assessed.

Main Results:

  • Healthy subjects demonstrated intrinsic connectivity between the ATL and modality-selective cortices.
  • svPPA patients exhibited ATL degeneration and reduced integrity in connected distributed regions.
  • Deficits outside the ATL correlated with semantic task performance and ATL atrophy patterns.

Conclusions:

  • The findings support a neurophysiological model where semantic processing is orchestrated by interactions between an ATL hub and modality-selective nodes.
  • This study provides evidence for the ATL's critical role in integrating distributed semantic information.