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Interleukin 6(-174G/C) variant and its circulating levels in coronary artery disease patients and their first degree

Rajesh Kumar Galimudi1, Mrudula K Spurthi, Chiranjeevi Padala

  • 1Department of Genetics, Osmania University, Hyderabad, Andhra Pradesh, India.

Inflammation
|September 28, 2013
PubMed

Insights

Interleukin-6 (IL-6) and C-reactive protein (CRP) levels are elevated in coronary artery disease (CAD) patients and their relatives. IL-6 gene variants (-174 G>C) are associated with increased risk, identifying at-risk individuals.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Genetics

Background:

  • Inflammation plays a key role in the development of coronary artery disease (CAD).
  • Interleukin-6 (IL-6) is a significant inflammatory cytokine implicated in CAD pathogenesis.
  • Identifying individuals at risk for CAD is crucial for preventative strategies.

Purpose of the Study:

  • To assess serum levels of IL-6 and C-reactive protein (CRP) in CAD patients and their first-degree relatives (FDRs).
  • To analyze the IL-6 gene -174 (G>C) polymorphism in relation to CAD.
  • To identify FDRs at risk for developing CAD.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) for IL-6 and latex agglutination for CRP.
  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for IL-6 genotyping.
  • Study included 600 subjects: CAD patients, FDRs, and healthy controls.

Main Results:

  • Significantly higher IL-6 and CRP levels were observed in CAD patients and FDRs compared to controls.
  • IL-6 genotype frequencies differed significantly among CAD patients, FDRs, and controls.
  • The CC genotype of IL-6 showed a significant association with higher serum IL-6 levels in CAD patients and FDRs (p<0.01).

Conclusions:

  • Inflammation, indicated by IL-6 and CRP, is integral to CAD pathogenesis.
  • IL-6 gene polymorphism is a potential biomarker for predicting CAD risk.
  • This study highlights the utility of IL-6 assessment in identifying asymptomatic FDRs at risk for future coronary events.

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