Related Experiment Video
Updated: May 7, 2026

05:55
Induction of Leptomeningeal Cells Modification Via Intracisternal Injection
Published on: May 7, 2020
Meningoencephalitis due to Gemella haemolysans
Benjamin T Galen1, David B Banach2, Melissa R Gitman3
1Department of Internal Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Journal of Medical Microbiology
|September 28, 2013
Summary
Gemella haemolysans can cause invasive infections. Direct 16S rRNA gene PCR and sequencing can diagnose G. haemolysans meningitis when cerebrospinal fluid cultures are negative.
Area of Science:
- Microbiology
- Infectious Diseases
- Neurology
Background:
- Gemella haemolysans is a rare cause of human invasive disease.
- Bacterial meningitis requires prompt diagnosis and treatment.
Observation:
- A case of meningitis caused by Gemella haemolysans is presented.
- The cerebrospinal fluid culture was negative for bacterial growth.
Findings:
- Direct 16S rRNA gene PCR and sequencing identified Gemella haemolysans in cerebrospinal fluid.
- This technique is valuable for diagnosing culture-negative meningitis.
Implications:
- Highlights the utility of molecular methods in diagnosing unusual bacterial meningitis.
- Suggests considering 16S rRNA gene PCR for suspected meningitis with negative cultures.
Related Concept Videos
Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
