Related Experiment Video
Updated: May 7, 2026
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
Adapting social neuroscience measures for schizophrenia clinical trials, Part 1: ferrying paradigms across perilous
Michael F Green1, Junghee Lee, Kevin N Ochsner
1To whom correspondence should be addressed; David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, UCLA, 760 Westwood Plaza, Rm 77-361, Los Angeles, CA 90024-1759, US; tel: 310-268-3376, fax: 310-268-4056,
Abstract:
Social cognitive impairment is prominent in schizophrenia, and it is closely related to functional outcome. Partly for these reasons, it has rapidly become a target for both training and psychopharmacological interventions. However, there is a paucity of reliable and valid social cognitive endpoints that can be used to evaluate treatment response in clinical trials. Also, clinical studies in schizophrenia have benefited rather little from the surge of activity and knowledge in nonclinical social neuroscience. The National Institute of Mental Health-sponsored study, "Social Cognition and Functioning in Schizophrenia" (SCAF), attempted to address this translational challenge by selecting paradigms from social neuroscience that could be adapted for use in schizophrenia. The project also evaluated the psychometric properties and external validity of the tasks to determine their suitability for multisite clinical trials. This first article in the theme section presents the goals, conceptual background, and rationale for the SCAF project.
