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Related Experiment Videos

Theophylline down-regulates adenosine receptor function.

J Mally1, J H Connick, T W Stone

  • 1Dept. of Pharmacology, University of Glasgow, U.K.

Brain Research
|February 12, 1990
PubMed
Summary
This summary is machine-generated.

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Chronic theophylline treatment in mice alters brain adenosine receptor function, not just number. This suggests that increased adenosine receptor numbers may not always correlate with enhanced receptor activity.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Receptor Biology

Background:

  • Chronic caffeine or theophylline administration in animals reportedly increases central nervous system (CNS) adenosine receptors, primarily measured by ligand binding.
  • Few studies have investigated the functional consequences of these receptor number changes.

Purpose of the Study:

  • To investigate the functional impact of chronic theophylline treatment on adenosine receptor activity in the mouse cerebral cortex.
  • To determine if changes in adenosine receptor number correlate with functional alterations.

Main Methods:

  • Electrophysiological recordings in mouse cerebral cortex slices to measure responses to N-methyl-D-aspartate (NMDA).
  • Acute and chronic administration of theophylline to assess its effects on adenosine-mediated responses.

Related Experiment Videos

  • Evaluation of theophylline's impact on responses to (-)-isoprenaline and 5-hydroxytryptamine.

    • Main Results:

    • Adenosine enhanced NMDA-induced depolarizing responses in mouse cerebral cortex slices.
    • Acute theophylline blocked this adenosine effect, but theophylline administered 24 hours prior did not.
    • Two weeks of theophylline treatment (10 or 100 mg/kg/day) abolished adenosine's effectiveness, with sensitivity gradually recovering thereafter.
    • Theophylline treatment reduced sensitivity to (-)-isoprenaline but not 5-hydroxytryptamine.

    Conclusions:

    • Chronic theophylline treatment induces functional changes in adenosine receptors in the mouse brain.
    • Increased adenosine receptor number, as detected by ligand binding, does not necessarily equate to increased receptor function.
    • Pharmacological interventions targeting adenosine receptors may have complex functional outcomes beyond simple receptor upregulation.