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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Rebelling for a reason: protein structural "outliers".

Gandhimathi Arumugam1, Anu G Nair, Sridhar Hariharaputran

  • 1National Centre for Biological Sciences, Tata Institute of Fundamental Research, Gandhi Krishi Vigyana Kendra Campus, Bangalore, India.

Plos One
|September 28, 2013
PubMed
Summary

Protein structural divergence can significantly impact function, even within the same superfamily. Careful consideration is needed when predicting protein function based solely on structural conservation, especially at low sequence identities.

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