Related Experiment Video

Updated: May 7, 2026

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

Resveratrol Inhibits CD4+ T cell activation by enhancing the expression and activity of Sirt1

Ting Zou1, Yi Yang, Fei Xia

  • 1Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province, People's Republic of China.

Plos One
|September 28, 2013
PubMed

Insights

Resveratrol, a natural compound, inhibits T cell activation and cytokine production by up-regulating Sirt1. This mechanism reduces inflammation, as seen in collagen-induced arthritis models.

Area of Science:

  • Immunology
  • Molecular Biology
  • Pharmacology

Background:

  • Resveratrol, a natural polyphenol, exhibits diverse biological effects.
  • Its precise role and molecular mechanisms in T cell activation remain debated.
  • Understanding resveratrol's impact on T cells is crucial for therapeutic applications.

Purpose of the Study:

  • To investigate the effects of resveratrol on T cell activation and cytokine production.
  • To elucidate the molecular mechanisms underlying resveratrol's action on T cells.
  • To evaluate resveratrol's therapeutic potential in an inflammatory disease model.

Main Methods:

  • In vitro and in vivo experiments assessing T cell activation and cytokine levels.
  • Manipulation of Sirt1 expression in T cells.
  • Analysis of c-Jun acetylation and translocation.
  • Assessment of collagen-induced arthritis in mice.

Main Results:

  • Resveratrol significantly inhibited T cell activation and cytokine production.
  • Sirt1 expression was upregulated by resveratrol in T cells.
  • Down-regulating Sirt1 diminished resveratrol's inhibitory effects on T cell activation.
  • Resveratrol decreased c-Jun acetylation and impeded its translocation.
  • Resveratrol treatment reduced the incidence and severity of collagen-induced arthritis.

Conclusions:

  • Resveratrol inhibits T cell activation and cytokine production, partly through Sirt1 upregulation.
  • The mechanism involves decreased c-Jun acetylation and translocation.
  • Resveratrol demonstrates therapeutic potential for inflammatory conditions like arthritis.

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...